Baltimore Ravens vs San Francisco 49ers Prediction, Spread & Odds for Monday Night Football Week 16

Dec 1, 2019; Baltimore, MD, USA; Baltimore Ravens kicker Justin Tucker (9) kicks the game winning field goal as time expires in the fourth quarter against the San Francisco 49ers at M&T Bank Stadium. Mandatory Credit: Tommy Gilligan-USA TODAY SportsThe AFC-leading Baltimore Ravens visit the NFC-leading San Francisco 49ers on a Christmas edition of MNFThe Niners own the NFL’s longest win streak (six games) while the Ravens have the second-longest (four)See the Baltimore Ravens vs San Francisco odds, spread, and predictions for Monday Night Football

A Week 16 Christmas Day triple-header wraps up with arguably the game of the season. Occupying the #1 seed in the AFC, the Baltimore Ravens (11-3, 6-1 away, 9-5 ATS) pay a visit to the San Francisco 49ers (11-3, 5-1 home, 8-6 ATS), who currently hold the #1 seed in the NFC portion of the NFL playoff bracket.

Kickoff at Levi’s Stadium is scheduled for 5:15 pm PT/8:15 pm ET on Dec. 25, and the home team is a sizable favorite in this battle between the top-two favorites in the Super Bowl odds.

Baltimore Ravens vs San Francisco 49ers Odds

San Francisco, which opened as just a four-point favorite, is now 5.5-point chalk and -225 on the moneyline in the Week 16 NFL odds. The visiting Ravens, who are an NFL-best 6-1 on the road, come back as +190 underdogs to win straight-up.

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Odds as of Dec. 23 at ESPN Bet. New users claim an ESPN Bet promo code to bet on Sunday Night Football. 

The Ravens vs 49ers game total is sitting at 47.5, which has moved up two full points from 45.5 when the Week 16 odds opened last Sunday. San Francisco is currently 8-6 over/under on the season, while Baltimore is 6-8 on the season but 5-3 in its past eight games.

As one would expect based on the line movement, the NFL public betting splits for Ravens/49ers were all over San Francisco early in the week. As of late Friday night, the Niners were getting 75% of ATS handle and 64% of moneyline handle. A whopping 90% of game-total handle was on the over.

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Ravens’ Defense Stuffs Jaguars

Playing its second prime-time game in as many weeks, Baltimore is coming off a 23-7 road win over the Jacksonville Jaguars. The game was considerably more even than the final score suggests; the Jaguars moved the ball inside the Baltimore 40 on four separate occasions in the first half and had zero points to show for it thanks to two missed field goals, a fumble, and poor clock management at the end of the half.

Oh my… that is absolutely BRUTAL clock management by the #Jaguars not to spike the ball.

Jacksonville left so many points on the board this half. 10-0 #Ravens. pic.twitter.com/310M5gjYkm

— JPAFootball (@jasrifootball) December 18, 2023

Baltimore’s performance on offense was more complete than the defensive side of the ball. Lamar Jackson and company racked up 251 rushing yards and 399 total yards, averaging 5.7 yards per carry.

Jackson now sits second in the NFL MVP odds, trailing only the man he’ll be battling on Monday, San Francisco QB Brock Purdy.

Unfortunately speedy running back Keaton Mitchell was lost to a knee injury in the Jaguars game and is now on the IR. Mitchell had piled up 396 yards on just 47 carries over eight games this year (8.4 YPC).

Ravens vs 49ers Injury Reports

Mitchell isn’t the only Raven who came out of Week 15 hurt. Baltimore’s top two wide receivers, Zay Flowers (foot) and Odell Beckham Jr (undisclosed illness), are both listed as “questionable” on the latest Ravens vs 49ers injury report.  OBJ was back at practice on Friday, though, suggesting he’ll be fine by Monday.

Offensive tackle Ronnie Stanley (concussion), safety Marcus Williams (groin), and corner Jalyn Armour-Davis (concussion) are also questionable for the Ravens.

On the 49ers’ side, a litany of significant contributors are also listed as questionable, including: running back Elijah Mitchell (knee), wide receiver Jauan Jennings (concussion), defensive tackle Javon Hargrave (hamstring), linebacker Oren Bucks (knee), and defensive ends Arik Armstead (foot/knee) and Clelin Ferrell (ankle).

2024-25 NFL Defensive Player of the Year Odds TrackerRead More

Niners Throttle Cardinals for Sixth Straight Win

Since an almost inexplicable three-game losing streak mid-season, the 49ers have rattled off six straight wins while going 4-2 against the spread, most-recently downing the Cardinals 45-29 in Arizona.

Over the past six weeks, San Francisco has an 18.8 average margin of victory. Their ATS losses came during a 28-16 win over Seattle as 14.5-point favorites, and a 27-14 win over Tampa Bay as 13.5-point favorites.

The 49ers are first in the NFL in point differential on the season (+191) and first in DVOA by a wide margin. San Francisco’s +46.07 DVOA scores is not just 7.9 percentage points ahead of second-place Baltimore (+38.8%), it’s also 7.8 points higher than any team has registered in the  last four seasons.

Purdy is currently second in the league in passing yards (3,795), trailing only Miami’s Tua Tagovailoa (3,921) while his passer rating of 119.0 is 12.9 points higher than any other QB.

Brock Purdy did it AGAIN. The dude is on an absolute heater & he was launching the ball down the field vs Cardinals.

Brock Purdy STOLE MVP.

🆕All 22 QB Film Breakdown 👇👇👇

🎥: https://t.co/qgghWgcTIM pic.twitter.com/haNQs6UDEd

— Chase Daniel (@ChaseDaniel) December 19, 2023

Purdy’s security blanket Christian McCaffrey continues to lead the league in rushing yards (1,292), all-purpose yards (1.801), and total touchdowns (20, tied with Miami’s Raheem Mostert).

Ravens vs 49ers Prediction

With Flowers less than 100%, OBJ likely the same, and Mitchell on the shelf, the undermanned Baltimore offense is going to need another MVP-caliber performance from Jackson. But if there is one front seven in the league that’s equipped to deal with Jackson’s escapability, it’s Nick Bosa, Fred Warner, and the Niners.

The Ravens’ defense, meanwhile, isn’t going to find San Francisco as generous as the Jags were last week. Purdy is going to be able to move the ball just as easily as Trevor Lawrence did – likely better – but the 49ers drives are going to end in touchdowns, not gaffes.

I am going to buy this line up a point to San Francisco -6.5 to get it into plus-money as I fully expect the red-hot Niners to continue their league-wide domination against a banged-up Baltimore team that’s on the road for the second straight week.

BAL vs SF pick:  49ers -6.5 (+102)

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